What is The META Trial?
The META Trial* is the largest trial of metformin conducted in Africa. It is aimed at identifying a low-cost intervention to prevent or delay onset of diabetes in individuals living with HIV and pre-diabetes, who are on antiretroviral therapy (ART) in the continent.
Not only will it produce globally relevant evidence on this question, but in ancillary studies, we will compare diagnostic methods for diabetes and use various clinical data to describe diabetes and HIV-related complications in this population. Developing clinical skills and capacity for conduct of clinical trials is central to the capacity development aims of the META Trial.
Watch our video below to discover more.
*This trial is funded by the European & Developing Countries Clinical Trials (EDCTP) Partnership, which aims to contribute to the reduction of the individual, social, and economic burden of poverty-related infectious diseases in sub-Saharan Africa.
The META Trial Partners
Persons who have diabetes first pass from a phase of normal glucose through to pre-diabetes before diabetes onset. Pre-diabetes strongly predicts the risk of developing diabetes. Studies in different populations have shown that 10-20% of subjects with pre-diabetes progress to clinical diabetes each year, and 70% of these individuals can expect to go on to develop overt diabetes during their lifetime.
